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Am J Physiol Endocrinol Metab 299:E364E373 Youm Y-H, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, DAgostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD (2015) Ketone body -hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease

And over time this can be problematic, leading to a wide range of symptoms, such as tiredness, depression, insomnia and brain fog to name just a few

Nat Genet 39:914921

Unlike most peptides on this site, tesamorelin is FDA-approved (brand Egrifta / Egrifta SV) for one specific indication: reducing excess abdominal fat in HIV-associated lipodystrophy